The concern of a growing limitation/reduction of functionality of these sacred substances is one that recently hit a personal tone for me. It may or may not be common knowledge that there is a seemingly minute, but present percentage of the population to whom psychedelics have no effect. This percentage has more recently been noted in the work of Rick Straussman during his studies with Dimethyltryptamine. In his book “The Spirit Molecule,” Dr. Straussman echoes the previously reported observation of Terrence McKenna, stating that roughly 5% of individuals showed no effect to the administration of what some consider a top tier and life altering substance, DMT.
I bring this up because I recently came into contact/witnessed an unfortunate and frustrated individual who shows NO effect from moderate-high doses of ANY Serotonergic Psychedelics (ie Psilocybin, Dimethyltryptamine, LSD…etc)!?
This individual has used SSRI’s (Anti-Depressants) as well as SNRI’s (ADHD/ADD med) since the age of 10. However what is most concerning about this instance is not the somewhat expected ability of SSRI’s to block access of other beneficial substances during use,but that EVEN AFTER he has ceased taking these medications he is still unable to gain any effect with Serotonergic Psychedelics.
While there is limited research into the effect that SSRI’s have on psychedelic potency (due to their legal status), there is a growing concern spreading through psychedelic forums. Meanwhile advocates against the long-term us of SSRI’s, whether affiliated with the psychedelic community or not, have begun to sound an alarm.
SSRI’s have most recently been shown to permanently damage/alter the receptors to which they attempt to give benefit. Even killing off up to 60% of receptors (http://www.toxicpsychiatry.com/storage/Antidep%20Receptor%20alterations%20SSRI%20SNRI%20Wamsley%20%201987.pdf) , and causing developmental reduction of the frontal lobes of the brain! (Marangell et al. 2001, p.1059)
Even more disturbing are that “These drugs are capable of crossing the placenta and being transferred to the newborn during lactation. This report reviews the available information regarding the effects of SSRIs on the fetus and newborn; including long-term neurodevelopmental outcomes.” (http://www.ncbi.nlm.nih.gov/pubmed/16015372) &
**PLEASE do some well informed Research and SPREAD THE WORD about this growing concern for mental health, as well as it’s shared impact on the future of the Psychedelic Community. Many studies and ongoing research can be found online**
Starting points/articles regarding these issues can be found at: